泌尿系感染产超广谱β-内酰胺酶大肠埃希菌的检测与耐药性

Antibiotic resistance of extended- spectrum β- lactamases E .coli in the urinary system infection

目的：了解产超广谱β-内酰胺酶（ESBL）大肠埃希菌在泌尿系感染中流行情况与耐药性,为临床合理用药提供依据。方法：采用K-B纸片扩散法,测定166株大肠埃希菌对12种抗菌药物耐药性,同时使用E-test方法确定ESBL阳性菌株。结果：166株大肠埃希菌共检出ESBL阳性菌70株（42.2%）。亚胺培南对ESBL大肠埃希菌抗菌活性最好（100%）,其次为阿米卡星（81.3%）。结论：产ESBL大肠埃希菌多重耐药严重,治疗该菌泌尿系感染,亚胺培南应作为首选药物。

Objective： To understand the epidemic of ESBL E. coli in the urinary system infection and it＇s resistance to 12 antibiotics. Methods： The antibiotic resistance of 166 E.coli to 12 antibiotics was detected by using K - B scraps methods. The positive ease with ESBL was screened by E - test.Results：70 producing ESBL bacterias was deteced in 166E.eoli.lt＇s positive rate was 42.2%. The best effect of killing bacteria was lmipen- era. It＇s susceptibility was 100% ,secondly was Amikcacin（81.3% ）. Conclusion： The muhidrug resistance was serious in the producing ESBL baeterias. Imipenem shoule be applied firstly in the treatment to the infection of the producing ESBL baeterias.