非小细胞肺癌外科治疗现状和进展

Current Status and Progress of Surgical Treatment of Non-Small Cell Lung Cancer

肺癌是对人类健康危害最大的恶性肿瘤之一,其死亡率居恶性肿瘤死亡率之首位。肺癌的外科治疗已有70余年历史,手术技术日臻成熟,已出现了以视频辅助胸腔镜为代表的微创胸外科技术,但肺癌外科治疗疗效并无明显提高。近年来,数个大型Ⅲ期前瞻性随机对照临床研究证实,辅助化疗可显著延长肺癌手术后生存期。正确地手术前分期,严格掌握肺癌手术适应证,降低手术创伤,规范肺癌根治性手术,减少围手术期合并症和坚持以循证医学为基础的个性化综合治疗是提高肺癌外科治疗结果的正确方向。

Lung cancer is the leading cause of cancer deaths worldwide in both men and women. Although the history of surgical treatment for lung cancer has been over 70 years and there have been great refinements in the staging and classification of lung cancer and advances in stage identification using minimally invasive technology, no dramatic improvements in the 5-year survival rates have been achieved. The treatment and prevention of lung cancer are major unmet needs that can better understanding of the mechanism and evolution of the disease will probably improve the treatment and prevention of lung cancer. Advances in preoperative staging and thoracic surgical techniques have reduced invasive procedures related to lung cancer diagnosis, staging, and treatment. This review will focus on major recent advances in the minimally invasive techniques for lung cancer staging, surgical technique and multimodality treatment for lung cancer. These progresses have facilitated defining optimal therapy and improving prognosis via individualized comprehensive treatment of lung cancer.