摘要
目的探讨急性有机磷中毒与心房颤动(房颤)的关系。方法回顾分析322例老年急性有机磷中毒患者的临床资料,选取其中36例发生房颤患者,同时选取年龄和性别均匹配的38例非房颤患者作为对照。对两组患者的胆碱酯酶(ChE)、心肌损伤标志物如肌酸肌酶(CK)及其同工酶(CKMB)、肌钙蛋白(cTn-1)进行对比分析。结果两组患者ChE均降低,房颤组ChE10~3300U/L,平均(U26.42±1047.02)U/L,非房颤组ChE(178~3700)U/L,平均(1604.82±934.06)U/L,房颤组低于非房颤组(t=2.077,P=0.041)。CK、CK-MB、cTn-I两组患者均有不同程度增高。CK:房颤组(80~2212)U/L,平均(609.97±597.84)U/L;非房颤组50~2200U/L,平均(462.84±530.71)U/L,两组差异无统计学意义(t=1.121,P—0.266)。CK—MB:房颤组8~468U/L,平均(97.31±104.50)U/L;非房颤组6~300U/L,平均(55.16±69.62)U/L,房颤组高于非房颤组(t=2.052,P=0.044)。cTn—I:房颤组1.2~5.0μg/L,平均(2.39±0.88)μg/L,非房颤组0.1~6.0μg/L,平均(1.81±1.38)μg/L,房颤组高于非房颤组(t=2.132,P=0.036)。结论急性有机磷中毒致房颤与ChE活力降低、乙酰胆碱(ACh)蓄积、心肌损伤可能有密切关系。
Objective To explore the relationship between acute organophosphate poisoning and atrial fibrillation (AF). Methods Three hundred and twenty-two acute organophosphorus poisoning of elderly patients treated from January 2000 to June 2008 in our hospital were analyzed. Among these patients, 36 cases with AF were selected as case group and 38 age gende〉matched cases without AF were selected as control group. Serum cholinesterase (ChE), myocardial damage markers such as creatine kinase (CK), creatine kinase-MB isoenzyme (CK MB) and Troponin I (cTn-I) were compared between the two groups. Results ChE was decreased in the two groups, and ChE was lower in case group than in control group ((1126.42±1047.02) vs. (1604.82±934.06)U/L, t= 2.07, P= 0. 0414]. CK, CK-MB and cTn-I were increased in different degree in the two groups. There was no difference in CK between the two groups ((609.97±597.84)U/L vs. (462.84± 530.71)U/L, t =1.121,P=0.266]. CK-MB and cTn I were higher in case group than in control group ((97.31±104.50) vs. (55. 16±69.62)U/L, t=2. 052,P=0. 0438;(2.39±0.88) vs. (1.81± 1.38) μg/L, t=2. 132, P = 0. 036, respectively] . Conclusions AF caused by acute organophosphate poisoning may be related to the decrease of ChE activity, acetylcholine accumulation and myocardial injury.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2009年第6期460-461,共2页
Chinese Journal of Geriatrics
关键词
中毒
有机磷化合物
心房颤动
Poisoning
Organophosphorlls compounds, Atrial fibrillation