新疆鼻咽癌226例临床病理分析

Clinicopathologic analysis of 226 cases nasopharyngeal carcinoma in Xinjiang

目的研究．LMP1在新疆地区鼻咽癌中的表达及EB病毒与鼻咽癌的关系。方法应用免疫组化法检测100例鼻咽癌中EBVLMP1的表达情况。结果100例鼻咽癌中，LMP1阳性表达为60％（60／100），35例淋巴结转移病例中，LMP1阳性表达为80％（28／35）。EB病毒LMP1阳性表达与鼻咽癌淋巴结转移显著相关，与年龄、性别、民族及组织分型无明显相关性。结论新疆地区鼻咽癌与EBV感染密切相关，EBVLMP1在鼻咽癌发生、发展中扮演重要角色。

Objective To study the expression of LMP1 in nasopharyngeal carcinoma in Xinjiang and the relationship between EB virus and nasopharyngeal carcinoma. Methods The expression of EBVLMP1 in 100 cases of nasopharyngeal carcinoma by immunohistochemistry. Results The positive expression rate of LMP1 at 100 patients with nasopharyngeal carcinoma was 60% （60/100）. The positive expression rate of LMP1 at 35 patients with lymphatic metastasis was 80% （28/35）. The positive expression of EBVLMP1 was correlated with lymphatic metastasis and irrelevant to age, gender, national, histological type. Conclusions Nasopharyngeal carcinoma in Xinjiang and EBV infection is closely correlation, EBVLMP1 play an important role in nasopharyngeal carcinoma and development.