雷公藤多苷联合泼尼松治疗老年肾病综合征的疗效观察

Effect of tripteryginm wilfordii together with predulsone in treatment of elderly primary nephrotic syndrome

目的观察雷公藤多苷联合中小剂量泼尼松治疗老年原发性肾病综合征的疗效。方法78例老年原发性肾病综合征患者随机分为治疗组（n=42）和对照组（n=36），治疗组接受雷公藤多苷联合中小剂量泼尼松治疗，对照组接受大剂量泼尼松治疗。治疗期间定期监测24h尿蛋白、血清白蛋白、肾功能、血脂等指标，观察疗效及复发率。结果治疗6个月后治疗组完全缓解24例，部分缓解12例，无效6例，对照组分别为13例、10例、13例。治疗组总缓解率为85．7％，明显高于对照组的66．7％（P〈0．05）；治疗组复发率为14．3％，明显低于对照组的36．1％（P〈0．05）。结论雷公藤多苷联合泼尼松治疗老年原发性肾病综合征疗效优于单纯应用泼尼松。

Objective To investigate the therapeutic effect of tripteryglum wilfordli and prednisone in old patients with primary nephrotie syndrome. Methods 78 elderly primary nephrotie syndrome patients were randomly divided into two groups. 42 patients in treated-group were treated with tripterygium wiffordii and prednisone while 36 patients in control-group were treated with prednisone only. The curative effect ,24 hours urinary protein, serum albumin, plasma lipid and renal function were detemined after six months. The responses of the patients were classified as complete remission（CR） ,partial remission（PR） and NO-response. Results After six months treatment, there were 24 patients got to CR,12 patients to PR,and 6 patients remained refractory to treatment group. While there were 13 patients got to CR,10 to PR,and 13 as refractory in the control group. The general effective rate in the treatment group was 85.7% ,which was markedly higher than that of the control group,which is 66. 67% （P 〈0. 05）. The recurrence rate in the treatment group and control group were 14. 3% and 36. 1% respectively （ P 〈 0. 05 ）. Conclusion The curative effect of tripterygium wilfordii and prednison on elderly primary nephrotie syndrome is markedly better than prednisone only.