丙泊酚在慢性阻塞性肺疾病机械通气中的镇静效果观察

Sedative effect of propofol used in mechanical ventilation patients in the exacerbation of chronic obstructive puhnonary disease

目的了解丙泊酚在慢性阻塞性肺疾病（COPD）急性加重期机械通气中的镇静效果。方法对35例COPD机械通气后采用丙泊酚镇静治疗，观察镇静效果达Ramsay Ⅲ-Ⅳ的时间、动态检测给药前、后和停药时呼吸、循环参数的变化，并与治疗前比较。结果丙泊酚起效时间（51．3±3．80）s，使用药物后绝大部分时间（85％）Ramsay分级维持在Ⅲ～Ⅳ级，镇静效果满意；停药后唤醒时间（5．8±4．9）min，患者无不良反应。用药后血压、心率逐渐稳定，呼吸频率、血氧饱和度、动脉血氧分压、动脉二氧化碳分压明显改善（P〈0．05）。结论丙泊酚用于COPD急性加重期机械通气的镇静治疗是安全有效的。

Objective To investigate the effect of propofol used in mechanical ventilation patients in the exacerbation of chronic obstructive pulmonary disease（COPD）. Methods 35 patients who received mechanical ventilation and sedated by propofol were observed in the exacerbation of COPD. The time to get Ramsay sedation level Ⅲ～Ⅳ was observed. The parameters of pneusis and circulation before, after giving propofol and withdrawl were compared. Results The sedative time of propofol was （51.3±3.80） seconds. In the most time（85% ） ,the level of Ramsay sedation was maintained at Ⅲ～Ⅳ after the usage of propofol. The time of awake from anesthesia was （5.8 ± 4. 9） minutes, and the patients had no adverse reactions. The blood pressure ,heart rate of patients were stable. And the parameters of respiratory rate, SaO2 , arterial partial pressure of oxygen and partial pressure of carbon dioxide in artery were improved significantly（ P 〈 0. 05 ）. Conclusion The sedative effect of propofol is safe and effective in patients re- quired mechanical ventilation in the exacerbation of COPD.