速尿联合硫酸镁雾化吸入治疗婴幼儿毛细支气管炎临床观察

目的探讨速尿联合硫酸镁雾化吸入治疗婴幼儿毛细支气管炎的疗效及安全性。方法312例毛细支气管炎患儿随机分为观察组和对照组各156例,2组患儿均给予抗病毒、止咳平喘、输氧、纠正水电解质紊乱等综合治疗,观察组在此基础上给予速尿0.5～1.0mg/kg、25%硫酸镁溶液0.1～0.3ml/kg+生理盐水20ml,用氧气驱动面罩吸入,2～3次/d。对照组则给予速尿、硫酸镁等同量静脉滴注。2组疗程均为7d。结果⑴观察组治愈率和总有效率明显高于对照组(P均0.001);⑵观察组发热、咳嗽、喘息、肺部音持续时间和住院时间均比对照组明显缩短(P均0.001);⑶观察组血氧分压和血氧饱和度均明显高于对照组(P均0.001);⑷2组均未出现明显不良反应。结论速尿联合硫酸镁雾化吸入治疗婴幼儿毛细支气管炎疗效确切、安全性好,治疗方法简便易行,婴幼儿家长易于接受,尤其适合在基层医院儿科推广应用。

Objective To study the therapeutic effect and safety of spray inhalation of Furosemide plus Magnesium Sulfate on infants with bmnchiolitis.Methods A total of 312 patients with bronchiolitis were randomly divided into two groups： observation group and control group.Based on symptomatic treatment, observation group was treated with spray inhalation of Furosemide plus Magnesium Sulfate, control group was treated with intravenous drip Furosemide plus Magnesium Sulfate. Results （1）The cure rate and total effective rate of observation group were higher than those in control group （all P〈0.001）; （2）The duration of fever, cough, gasp,pulmonary rale and hospital stay in observation group were shorter than those in control group（all P〈0.001）; （3）Blood oxygen pressure and blood oxyen saturation of observation group were higher than those in control group（all P〈 0.001）; （4）No side effect was observed in two groups. Conclusion Spray inhalation of Furosemide plus Magnesium Sulfate treated infants bronchiolitis is safe and effective.It is worthy of application.