基于拟氨基酸编码方法的同义密码子的偏好性与结合强度的相关性研究

Correlation between the usage degree of the synonymous codon and the strength of combination based on the quasi-amino acid coding

计算了基于拟氨基酸编码方法下的同义密码子的相对使用度,分析了78个人类基因(19967个密码子)中基于拟氨基酸编码方法下的同义密码子的偏好使用情况.石秀凡等的研究结果显示了人类基因中基于基因组基因编码方法下,对同义密码子的选择在所有密码子家族中仍都呈现明显一致的偏好.即偏好使用密码子-反密码子结合作用强的密码子,恰好是以c结尾的密码子;且避免使用结合作用中度的密码子.依据结果和数据分析,推测人类基因对密码子的选择除了受基因组结构中isochore和基因签名的影响外,还和密码子-反密码子结合强度密切相关.这些因素共同作用于人类基因,从而在所有密码子家族中都呈现出对同义密码子明显一致的偏好现象.文中则是展示了上述性质在拟氨基酸编码方法下,这些特征不但存在,而且更为明显.

The relative usage degree of the synonymous codon is computed and the use of preferences of the synonymous codon in 78 human genes（ 19967 codons） is analysed based on the quasi-amino acids coding. The results of Shi Xiufan et al. show that human genes clearly show the consistent preference in synonymous codon choice in all codon family based on the genomie genetic codes. That is, human genes prefer to use the codons with strong combination of the codon-anticodon, the codons ending with c, so that the use of the codons with moderate combination is avoided. The choice of codon in human genes is not only affected by the isochore and genome in the genome structure, but also related to the strength of combination with the codon-anticodon. All the above-mentioned factors affect the human genes, and so all the codon families clearly show the consistent preference to the synonymous codon. This study shows that the above-mentioned characterities are more obvious when the method of quasi-amino acids coding is used.