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GRIN1基因-855G/C和-1140G/A位点遗传多态性 被引量：1

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摘要 谷氨酸（glutamate．Glu）是哺乳动物脑内重要的兴奋性神经递质．Glu通过作用其受体发挥着重要的生物学功能。Glu受体基因存在单核苷酸多态性（single nueleotide polymorphism．SNP），为探讨其在法医学中的应用价值．本研究调查了Glu受体基因之一GRIN1启动子区域-855G／C与-1140G／A2个SNP位点在中国北方汉族群体中的频率分布。
作者 李忠杰 王保捷 丁梅 庞灏 孙雪菲 杨俊 宣金锋 邢嘉鑫
机构地区 中国医科大学法医学院法医血清学教研室
出处 《法医学杂志》 CAS CSCD 2009年第3期217-218,共2页 Journal of Forensic Medicine
基金 辽宁省教育厅高等学校科研项目(2004D052)
关键词 法医遗传学 多态性 单核苷酸 GRIN1 北方汉族群体
分类号 R392.12 [医药卫生—免疫学] R394 [医药卫生—医学遗传学]
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参考文献5

  • 1李忠杰,王保捷,丁梅,庞灏,孙雪菲,杨俊.谷氨酸受体基因单核苷酸多态性与精神分裂症的关联[J].法医学杂志,2008,24(5):369-374. 被引量：6
  • 2Hung CC,Chert HY,Chen CH.Systematic mutation analysis of the human glutamate receptor,ionotropic,N-methyl-D-aspartate 1 gene(GRIN1) in schizophrenic patients[J].Psychiatr Genet,2002,12(4):225-230.
  • 3Begni S,Moraschi S,Bignotti S,et al.Association between the G1001C polymorphism in the GRIN1 gene promoter region and schizophrenia[J].Biol Psychiatry,2003,53(7):617-619.
  • 4Georgi A,Jamra RA,Schumacher J,et al.No association between genetic variants at the GRIN1 gene and bipolar disorder in a German sample[J].Psychiatr Genet,2006,16(5):183-184.
  • 5Galehdari H.Association Between the G1001C Polymorphism in the GRINI Gene Promoter and Schizophrenia in the Iranian Population[J].J Mol Neurosci,2009,37 (1):95.

二级参考文献27

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共引文献5

同被引文献7

  • 1VanDongen AM, VanDongen HM. Effects of mRNA untranslated regions on translational efficiency of NMDA receptor subunits[J]. Neurosignals, 2004,13 (4) : 194-206.
  • 2Hung CC, Chen HY, Chen CH. Systematic mutation analysis of the human glutamate receptor, ionotropic, N-methyl-D-aspartate 1 gene (GRIN1) in schizophrenic patients[J]. Psychiatr Genet,2002,12(4) :225-230.
  • 3Begni S, Moraschi S, Bignotti S, et al. Association between the G1001C palymorphism in the GRIN1 gene promoter region and schizophrenia[J]. Bial Psychiatry, 2003,53 (7) :617-619.
  • 4Zhao X, Li H, Shi Y, et al. Significant association between the genetic variations in the 5' end of the N-methyl-D-aspartate receptor subunit gene GRIN1 and schizophrenia[J]. Bial Psychiatry, 2006,59 (8) : 747-753.
  • 5Galehdafi H, Pooryasin A, Foroughmand A, et al. Association between the G1001C palymorphism in the GRIN1 gene promoter and schizophrenia in the Iranian population[J]. J Mal Neurosci,2009,38(2):178-181.
  • 6Schork NJ, Greenwood TA, Braff DL. Statistical genetics concepts and approaches in schizophrenia and related neuropsychiatric research[J]. Schizophr Bull,2007, 33(1 ) :95-104.
  • 7李忠杰,王保捷,丁梅,庞灏,孙雪菲,杨俊.谷氨酸受体基因单核苷酸多态性与精神分裂症的关联[J].法医学杂志,2008,24(5):369-374. 被引量：6

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法医学杂志
2009年 第3期

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