固本汤联合放射治疗食管癌术后患者疗效观察

Clinical Effect of Guben Decotion Combined with Radiotherapy in Treatment of Patients with Esophageal Carcinoma after Surgery

目的观察固本汤联合放射治疗对食管癌术后患者疗效的影响。方法选择2002年4月～2006年9月64例食管癌术后患者,随机分为A组(单纯放疗)和B组(固本汤+放疗),观察消化道反应、骨髓抑制、放射性反应和生存期、放疗前后Karnofsky评分,对比两组肿瘤患者的毒副反应和疗效。结果放疗结束按Karnofsky评分,B组明显高于A组,差别显著;B组1、2、3年生存率明显优于A组,差异显著;毒副反应两组对比,消化道反应、骨髓抑制及放射性食管炎(残胃炎)差异有显著性,B组明显低于A组,主要表现为恶心呕吐、白细胞下降,吞咽疼痛及反酸,一般经对症处理均能缓解。结论固本汤联合放射治疗能明显降低毒副反应,提高食管癌术后患者的生存质量,延长生存期。

Objective To observe the effect for the patients with esophageal carcinoma surgery by guben decotion combined with radiotherapy. Methods 64 cases of patients with esophageal carcinoma after surgery were randomly divided into two groups, patients in control group（n = 30） were treated by radiotherapy only. Patients in treatment group（ n = 34 ） were treated by guben decotion combined radiotherapy. Investigated the digestive tract response,the marrow suppression,the radioactive response and the lifetime,the Karnofsky grading after the radiotherapy,contrasted two group of tumor patient＇s poisonous side reaction and the curative effect. Results B group of Karnofsky grading is higher than A group obviously ; B group of lifetimes surpass A group obviously; B group of poisonous side reactions are lower than A group obviously. Conclusion The lifequality and lifetime of the patients with esophageal carcinoma after surgery treated by guben decotion combined with radiotherapy were improved obviously, and the poisonous side reaction of the radiotherapy were reduced obviously.