新生儿呼吸机相关肺炎病原菌及药敏分析

The Clinical Analysis of Bacteria and Drug Sensitivity in Neonatal Ventilator-associated Pneumonia

目的探讨NICU中新生儿呼吸机相关肺炎(Ventilator-associated pneumonia,VAP)病原菌的分布及耐药情况。方法选取128例VAP新生儿,分析其深部气管分泌物病原菌及药敏分析情况。结果123例新生儿培养阳性,其中革兰阴性杆菌占85.57%,主要为肺炎克雷伯菌、鲍曼不动杆菌、阴沟肠杆菌、铜绿假单胞菌、大肠埃希菌,且对主要抗生素广泛耐药。结论新生儿VAP中主要致病菌是以革兰阴性杆菌为主。本病的混合感染和多重耐药是重要的临床特征。

Objective To detect the bacteria and drug sensitivity in new borns with ventilator-associated pneumonia. Methods The study included 128 new borns. We detected the bacteria and drug sensitivity of trachea secretion in neonatal VAP. Results Klebsiella pneumonia, acinetobacter baumannii, enterobacter cloacae, pseudomonas aerubinosa and escherichia coli were the most common bacteria in VAP. They were widely resistance to main antibiotics. Conclusion Gram-negative bacilli are the most bacteria. Mixed infection and muhidrug resistance are important clinical characteristic in VAP.