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宫颈癌及癌前病变组织中COX-2 mRNA的表达及临床意义 被引量:4

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摘要 目的为寻找宫颈癌早期的基因诊断指标及基因治疗方法提供依据。方法应用半定量RT-PCR方法检测宫颈癌及宫颈癌前病变组织中的COX-2mRNA的表达水平。结果COX-2mRNA在宫颈癌中的表达率和相对含量高于宫颈CINⅢ及原位癌和慢性宫颈炎组织。其在宫颈CINⅢ及原位癌和慢性宫颈炎组织中的表达率及相对含量比较均无明显差异(P>0.05)。结论宫颈癌组织、宫颈CINⅢ及原位癌组织中存在COX-2的表达,COX-2mRNA的表达与癌早期的形成、分期、分化无明显关系(P>0.05),与淋巴结转移有显著性差异(P<0.05)。
作者 徐凤梅 王敏
出处 《中国现代医生》 2009年第17期33-34,共2页 China Modern Doctor
关键词 宫颈癌 COX-2 RT-PCR
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