摘要
肿瘤的发生与发展涉及多种受体或信号通路网络。多项研究结果表明,多靶点药物的治疗效果优于单靶点药物,多靶点抑制肿瘤信号转导是肿瘤防治药物重要的研究方向。本文根据化学结构分类,对多靶点蛋白酪氨酸激酶抑制剂及其发展前景做简要综述。
The growth and development of cancer involve in more than one receptors and signal path-ways. Recent data have shown that multi-targeted drugs could be much more efficient than drugs directed at a single target. Blocking multiple signal transduction pathways simultaneously has become an important new direction in tumor therapeutic agent discovery. The development of multi-targeted tyrosine kinase inhibitors is reviewed based on their chemical structures.
出处
《国际药学研究杂志》
CAS
2009年第3期161-171,共11页
Journal of International Pharmaceutical Research
基金
国家973计划资助项目(No.2004CB518903)
关键词
肿瘤
多靶点
酪氨酸激酶抑制剂
抗肿瘤药
信号转导
neoplasms
muhiple-target
protein tyrosine kinase inhibitor
antineoplastic agents
signal transduction