多靶点蛋白酪氨酸激酶抑制剂的研究进展

Multi-targeted protein tyrosine kinase inhibitor:research advances

肿瘤的发生与发展涉及多种受体或信号通路网络。多项研究结果表明,多靶点药物的治疗效果优于单靶点药物,多靶点抑制肿瘤信号转导是肿瘤防治药物重要的研究方向。本文根据化学结构分类,对多靶点蛋白酪氨酸激酶抑制剂及其发展前景做简要综述。

The growth and development of cancer involve in more than one receptors and signal path-ways. Recent data have shown that multi-targeted drugs could be much more efficient than drugs directed at a single target. Blocking multiple signal transduction pathways simultaneously has become an important new direction in tumor therapeutic agent discovery. The development of multi-targeted tyrosine kinase inhibitors is reviewed based on their chemical structures.