闵行区40～74岁无糖尿病史人群代谢综合征患病特征及影响因素

Analysis on the prevalence and the influencing factors of metabolic syndrome of 40～74 year-old non-diabetes population in Minhang District

目的旨在了解闵行区40～74岁无糖尿病史人群代谢综合征(MS)患病特征及影响因素。方法利用闵行区2007年糖尿病筛查资料,以整群抽样的方法抽取闵行区2个街道,共3 947位40～74岁居民,全部进行75g无水葡萄糖耐量(OGTT)、甘油三酯(TG)、高密度脂蛋白(HDL-C)等测定和问卷调查。结果调查对象MS的标化患病率为8.52%,超重或肥胖、糖尿病、糖调节异常、高血压、高TG、低HDL-C标化患病率分别为15.67%、2.45%、5.60%、17.72%、16.47%、2.00%。男性的MS、超重或肥胖、糖尿病和高血压患病率高于女性。MS患病率随着年龄的增长而上升,50岁以上年龄段上升明显,45岁以上年龄段MS的患病率显示性别之间无显著差异。BMI、血压、血糖、TG与HDL-C异常人群的MS患病率明显高于正常人群,有BMI、血压、血糖、TG、HDL-C异常因素人群患MS的风险分别是正常人群的15.71、28.21、10.09、30.31、3.14倍,而MS人群的糖尿病、冠心病和脑卒中的患病率明显高于非MS人群,MS人群患糖尿病、冠心病、脑卒中的风险是非MS人群的10.09、9.94、2.40倍。MS相关影响因素多因素分析显示男性、高龄、有糖尿病家族史、无体力活动是MS的危险因素。结论MS和相关疾病严重威胁着闵行区40岁以上人群的健康。

Objective To understand the prevalence and Influencing factors of Metabolic Syndrome （MS） of 40-74 year-old non-diabetes population in Minhang District. Methods A population-based sample （diabetes screening of Minhang District in 2007） of 3 947 individuals aged 40- 74 years was investigated by cluster random sampling. They completed a questionnaire and underwent triglyceride, high density lipoprotein measured cholesterol and an oral glucose tolerance test. Results The standardized prevalence rate of MS, overweight, diabetes, impaired glucose regulation （IGR）, hypertension, high triglyceride and low HDL were 15.67% , 2.45%, 5.60%, 17.72%, 16.47% and 2.00%. The male with MS, overweight or obese, diabetes and hypertension were higher than the female in terms of incidence. The prevalence of MS was increased with age, the highest rate at the ages of 50 years and above. There was no significant difference between male and female at the ages of 45 years and above. The incidence of MS in people with BMI or hypertension or abnormal blood glucose or hige TG or low HDL-C was obviously higher than that of normal population. The OR value were 15.71, 28.21, 10.09, 30.31 and 3.14 respectively. The prevalence of diabetes, coronary heart disease and stroke in people with MS was higher than that of people with out MS. The OR value were 10.09,9.94 and 2.40. Multiple factor analysis showed that the factors related to MS were male, the aged, family history of diabetes and having no physical activity. Conclusions MS and realated diseases are a serious threat to population of 40 years old and above in Minhang District.