动脉化疗灌注及栓塞治疗胃癌的临床应用

Clinical application of arterial chemotherapy transfusion and embolization in treatment of gastric cancer

目的:探讨经动脉灌注化疗及栓塞治疗胃癌的疗效及临床应用价值。方法:25例经病理证实的不能手术的胃癌患者,经肿瘤供血动脉注入化疗药物后再进行化学栓塞。化疗药物为丝裂霉素10～20 mg,5-FU 1 000～1 250 mg,顺铂80～100 mg,栓塞剂选用乙碘油及PVA颗粒。结果:完全缓解(CR)3例,部分缓解(PR)17例,稳定(NC)2例,进展(PD)3例。近期总有效率80%,中位生存期为15.2个月,1、2、3年生存率分别为87%,62.5%,12.5%。结论:肿瘤供血动脉化疗灌注及栓塞治疗晚期胃癌不良反应轻,有较显著的临床应用价值。

Objective ：To evaluate the efficacy and the clinical value of arterial chemotherapy transfusion and embolization in treatment of gastric cancer. Methods： A total of 25 patients with inoperable gastric cancer confirmed by pathology were entered into the study. All eases were treated by means of artery embolization with lipiodol and PVA after chemotherapy transfusion （mitomyein 10~20 mg, 5-FU 1 000～1 250 mg,eisplatin 80-100 mg ） in the artery. Results：Among the 25 cases,3 showed complete response （CR）, 17 showed partial response （PR）, 2 showed no stable disease （SD）and 3 showed progressive disease （PD）.The overall response rate was 80% in the near future. The median survival time was 15.2 months. The 1-,2-,3- year survival rate respectively was 87%,62.5%, 12.5%. Conelusion：Embolization in the artery after chemotherapy transfusion has lower toxicity and significant clinical value in the treatment of inoperable gastric cancer.