米诺环素对急性心肌梗死病人心室功能的影响

Effect of minocycline on cardiac function in patients with acute myocardial infarction

目的:观察米诺环素对急性心肌梗死病人心室功能的影响。方法:将80例符合标准的急性心肌梗死(AMI)病人分为治疗组40例(首天加用米诺环素片剂0.2 g,2次/天,第二天开始为0.1 g,1次/天,直到28天)。对照组40例,两组的溶栓和常规治疗基本相同。应用超声检查两组7 d和28 d后左室舒张末期内径(LVEDD),左室收缩末期内径(LVESD)和左室射血分数(LVEF)。结果:7d后治疗组患者心脏LVEDD和LVESD较对照组无明显差异;但其LVEF较对照明显增加(P<0.05);28 d后治疗组病人心脏LVEDD,LVESD和LVEF均较对照组差异有显著性(P<0.05)。结论:米诺环素联合常规治疗能够改善AMI病人的心室功能。

Objective：To investigate the effect of minocycline on cardiac function in the patients with myocardial infarction. Methods：80 patients with acute myocardial infarction were divided into two groups：treated group （the first day minocycline, 0.2 g, b.i.d, and then 0.1 g,q.d from the 2 d to 28 d,n=40） and control group （n=40）.The methods of routine treatment were same in the two groups.Left ventricalar end-diastolic diameter （LVEDD） and left ventricular end-systolic diameter （LVESD）,Ieft ventricular ejection fraction （LVEF） were examined by Doppler ultrasound after 7 d and 28 d. Results：There was significant difference of LVEDD and LVESD between two groups; however, the LVEF increased significantly after 7 d （P〈0.05）. After 7 d,LVEDD and LVESD decreased, and LVEF increased significantly in the treated group compared with those in the control group. Conclusion：Minocycline could improve cardiac function in the patients with acute myocardial infarction.