血液灌流加血液透析抢救重症有机磷农药中毒疗效观察

Observation of effects of hemoperfusion associated with hemodialysis on severe organophosphorous poisoning

目的:探讨血液透析(HD)加血液灌流(HP)治疗重症有机磷中毒(AOPP)的临床疗效。方法:81例AOPP患者随机分成HD+HP组40例和对照组41例。HD+HP组在常规治疗基础上(阿托品+胆碱酯酶复活剂)加HD+HP治疗。结果:HP+HD组患者昏迷时间,血清胆碱酯酶(CHE)活性恢复时间、住院时间显著短于对照组(P<0.01),阿托品应用总量显著减少(P<0.01),死亡率显著降低。结论:HD+HP治疗AOPP疗效显著。

Objective：To investigate the treatment effects of hemodialysis（HD）and hemoperfusion（Hp） on severe organophosphorous insecticides intoxication.Methods： 81cases with severe organophosphorous inseeticides in toxication were divided into 2 groups,one was HP＋HD group and another was non-Hp＋HD group.The non-HP＋HD group received conventional treatment,while the Hp＋HD group received HP＋HD besides conven tional treatment.Results ：The time of coma, serum cholinesterase recovery and hospitalization in the HP＋HD group was markedly shorter than those in the non-HP＋HD group （P〈0.01）.The amount of atropine was markedly decreased,and the cure rate was increased significantly （P〈0.01）.The mortality of the HD＋HP group was lower than that of the control group.Conclusion： HD＋HP has obvious effect in treatment of AOPP.