转化生长因子β与骨关节炎的研究进展

Research Advancement on Transforming Growth Factor β and Osteoarthritis

转化生长因子β在软骨细胞代谢中发挥着十分重要的作用，可促进软骨基质分泌、细胞增生、骨软骨生成分化；短期关节腔内注射可增加骨和次级软骨细胞生成、骨软骨发生。转化生长因子β与骨关节炎病理改变有密切关系，参与了软骨细胞的破坏、软骨基质的降解、滑膜的反应性炎症、骨赘形成等。

Transforming growth factor-β （TGF-β）play an important role in chondrocyte metabolism, which participate in cartilage matrix secretion, proliferation, bone formation and differentiation, and bone cyto- poiesis and chondrogcnesis can be enhanced by intra-articular injection of TGF-β. The pathological changes of osteoarthritis is associated with TGF-β, which take part in destroy of chondrocyte, degradation of dartilageI matrix,synovial inflammation and osteophyte formation.