吲哚胺2,3二氧化酶与肿瘤免疫耐受

Indoleamine 2,3-dioxygenase and Tumor Immune Tolerance

肿瘤免疫耐受是一个获得性免疫应答的过程，许多机制参与调节。吲哚胺2，3-二氧化酶（IDO）是体内肝外色氨酸沿犬尿氨酸代谢的限速酶。其通过诱导“色氨酸删除”环境、色氨酸代谢产物的细胞毒性作用和调节Tregs等抑制T淋巴细胞增殖、活化，共同诱导肿瘤免疫耐受。抑制IDO可为今后肿瘤临床治疗提供新思路和方法。

Tumor immune tolerance is a process of acquired immune response involving many mechanisms. Indoleamine 2,3-dioxygenase （ IDO ） is the rate-limiting enzyme in the kynurenine pathway of tryptohan catabolism. IDO induces tumor immune tolerance hemisphere, which can inhibit T cell proliferation/activation,via inducing ＂ tryptohan depletion＂ environment, eytotoxieity of tryptohan metabolite and modulating Tregs. The inhibitors of IDO may provide a prosperous therapeutic method for tumors.