肝癌的实验室诊断研究新进展

New Research Progression in Laboratory Diagnosis of Liver Cancer

血清肿瘤标志物对肝癌的早期诊断、肿瘤进展的监测、疗效判定、复发和患者生存率的判断具有重要意义，临床常用的有甲胎蛋白（AFP）、甲胎蛋白异质体、异常凝血酶原（DCP）、血清铁蛋白、α-L-岩藻糖苷酶（AFU）、肝细胞生长因子与分子生物学检测p53基因等。近来新发现的甲胎蛋白免疫球蛋白M复合物（AFP-IgMIC）和人类印迹基因之一的DLK1可能将成为肝癌早期诊断的重要指标之一。

Serum tumor marker is very important to for early diagnosis, tumor progression monitoring, therapeutic effect evaluation, tumors recurrence and patients＇ survival prediction. AFP, AFP variants, DCP, ferritiu, AFU, HGF and molecular biology detection of P53 gene are important markers which are commonly used in clinical diagnosis of liver cancer traditionally. The recently discovered AFP-IgM IC and human imprinting gene（ DLK1 ） maybe become one of the most important indicators for the early diagnosis of liver cancer.