后海穴注射穿心莲和黄连素对小鼠实验性腹泻的影响

Effects of Andrographis Paniculata and Berberine Injected to Houhai Point on Anti-diarrhea of Mice

通过小鼠实验腹泻模型及小肠推进实验,研究后海穴注射穿心莲和黄连素的抗腹泻作用。结果表明,后海穴注射穿心莲和黄连素能显著降低番泻叶、高渗硫酸镁溶液所致小鼠实验性腹泻的发生率和腹泻频率(P<0.05),后海穴注射黄连素能极显著抑制番泻叶所致小鼠肠蠕动亢进(P<0.01)。实验结果提示,后海穴注射穿心莲和黄连素具有良好的抗腹泻作用,这与抑制小肠蠕动亢进有关。

The experimentally antidiarrheal effects of acupoint-inject at Houhai were examined by experimental diarrhea and intestinal hyperanakinesia. The results showed that acupoint - inject andrographitis and berberine at Houhai significantly reduced the incidence and frequency of experimental diarrhea induced by Cassia angustifolia leaf or hypertonic magnesium sulphate solution（ P 〈 0. 05 ） and acupoint -inject berberine significantly inhibited the intestinal hyperanakinesia induced by Cassia angnstifolia leaf （P 〈 0.01 ） in mice. These data suggested that acupoint - inject andrographitis and berberine at Houhai was role in the anti -diarrhea, which relating on inhibited of intestinal hyperanakinesia.