拉西地平合用阿托伐他汀对原发性高血压左室肥厚及舒张功能的影响被引量：13

Effect of lacidipine combination of atorvastatin on left ventricular hypertrophy and diastolic function in hypertensive patients

下载PDF

导出

摘要目的评价拉西地平合用阿托伐他汀对原发性原发性高血压左室肥厚及舒张功能的影响。方法将90例原发性原发性高血压左室肥厚患者随机分为A、B两组,A组给予拉西地平4mg/d;B组给予拉西地平4mg/d+阿托伐他汀10 mg/d。疗程6个月。分别在用药前、用药后6个月应用超声心动图检查评价心肌肥厚和左室舒张功能。结果两组治疗6个月后左室肥厚的逆转及舒张功能指标(E、A、E/A、IVRT)改善程度与用药前比较差异有统计学意义(P<0.05)。两组间比较B组明显优于A组(P<0.01)。结论拉西地平合用阿托伐他汀对原发性高血压左室肥厚逆转及舒张功能改善有协同作用,较单一用药疗效显著。 Objective To evaluate effect of Lacidipine combination of atorvastatin on hypertensive left ventricular hypertrophy and diastolic function. Methods Ninety cases of hypertension in patients with left ventricular hypertrophy were randomly divided into A,B groups,Group A with lacidipine 4mg/d and Group B with Lacidipine 4mg/d and atorvastatin 10mg/d were treated for 6 months, left ventricular hypertrophy and diastolic function were evaluated by echocardiography before and after 6 months of treatment. Results After 6 months, the levels of reversing left ventricular hypertrophy and improving parameters of diastolic function （E, A, E/A, IVRT） had significant differences before treatment （P〈0.05）. Comparison between two groups, Group B was better than Group A（P〈0.01）. Conclusion They had synergistic effects that lacidipine combination of atorvastatin reversed left ventricular hypertrophy and improved diastolic function. These synergistic effects were better than that that with a single drug significantly.

作者苟怀宇陈艳秋

机构地区重庆市渝北区人民医院心内科

出处《重庆医学》 CAS CSCD 北大核心 2009年第12期1506-1507,1509,共3页 Chongqing medicine

关键词拉西地平阿托伐他汀原发性原发性高血压左室肥厚舒张功能 lacidipine atorvastatin essential hypertension left ventricular hypertrophy diastolic function

分类号 R541.3 [医药卫生—心血管疾病]

引文网络
相关文献

参考文献7

1Steine K, Rosseb AB, Stugaard M, et al. Left ventricular systolic and diastolic function in asymptomatic patients with moderate aortic stenosis[J]. Am J Cardiol, 2008,102 (7):897.
2Seymour EM,Singer AA,Bennink MR, et al. Chronic intake of a phytochemical-enriched diet reduces cardiac fibrosis and diastolic dysfunction caused by prolonged saltsensitive hypertension[J]. J Gerontol A Biol Sci Med Sci, 2008,63(10) :1034.
3Segerson NM, Wasmund SL, Daccarett M, et al. The acute effect of atrioventricular pacing on sympathetic nerve activity in patients with normal and depressed left ventricular function[J]. Am J Physiol Heart Circ Physiol, 2008,295 (3) : H1076.
4Pozo M,de Nicolds R, Egido J, et al. Simvastatin inhibits the migration and adhesion of monocytie cells and disorganizes the cytoskeleton of activated endothelial cells[J]. Eur J Pharmacol, 2006,548 (1-3):53.
5van der Harst P, Groenewegen HC, Roks AJ, et al. Rosuvastatin attenuates angiotensin Ⅱ-induced neointimal formation after stent implantation in the rat[J]. Coron Artery Dis,2008,19(1):47.
6Singh U, Devaraj S, Jialal I, et al. Comparison effect of atorvastatin(10 versus 80 rag) on biomarkers of inflammation and oxidative stress in subjects with metabolic syndrome[J]. Am J Cardiol, 2008,102 (3):321.
7Tziakas DN,Chalikias GK, Stakos DA, et al. Effect of statins on collagen type Ⅰ degradation in patients with coronary artery disease and atrial fibrillation[J].Am J Cardiol, 2008,101 (2) : 199.