血清AFP、CA19-9、CA125、CEA、GGT联合检测对原发性肝癌的诊断价值

Value of combined messurement of serum AFP、CA 19-9、CA125、CEA、GGT leves for diagnosis of primary hepatic carcinoma

目的:探讨血清甲胎蛋白(AFP)、糖类抗原CA19-9、糖类抗原CA125、癌胚抗原(CEA)、γ-谷氨酰转肽酶(GGT)对原发性肝癌的诊断价值。方法:对39例原发性肝癌45例良性肝病及36名正常体检者血清AFP、CA19-9、CA125、CEA、GGT水平同步测定并进行对照。结果:AFP、CA19-9、CA125、CEA、GGT对原发性肝癌诊断的灵敏度依次为78.4%、70.3%、67.6%、48.6%和64.9%五项联合检测对原发性肝癌诊断的灵敏度可提高为94.6%。结论:多种肿瘤标志物联合检测对原发性肝癌的诊断具有重要价值。

Objective： To discuss the value of measurement of serum AFP, CA19 - 9, CA125, CEA, GGT leves for diagnosis of primary hepatic carcinoma（PHC）.Methods：AFP, CA19-9,CA125,CEA and GGT were measured in 39 PHC patients,45 patients with benign liver disease and 36 normal controls. Results： The sensitivity of AFP,CA19 - 9,CA125,CEA and GGT in the diangnosis of PHC was 78.4%, 70.3% ,67.6% ,48.6% and 64.9%, respectively. The combined measurement of 5 tumor marker selevated diagnostic specificity of PHC 94.6%. Conclusions： Combined measurement of tumor markers is valuable for diagnosis of PHC.