HCC患者多肽生长因子及肿瘤标志物测定的临床意义

Study on Clinical Significance of Determination of Changes of Serum TGF-α,TGF-β1,AFU and AFP Levels in Patients with Hepatocellular Carcinoma and Liver Cirrhosis

目的:分析血清多肽生长因子水平与肝硬化、肝癌的关系,初步探讨其发病机制。方法:采用放射免疫分析(RIA)测定32例肝癌(HCC)、34例肝硬化(LC)患者及30名正常对照组人员的血清TGF-α、TGF-β1、AFP及AFU水平四项指标。结果:HCC患者组血清TGF-α、TGF-β1、AFP及AFU水平均显著高于LC组及正常对照组(P均<0.05),LC组则AFP及AFU水平均显著高于正常对照组(P<0.05),但TGF-α、TGF-β1水平与正常对照组比较无显著性差异(P>0.05)。结论:HCC患者血清多肽生长因子TGF-α、TGF-β1、AFP及α-L、岩藻糖苷酶(AFU)水平发生了明显的变化,提示四项指标水平的升高及过度表达与肝癌的恶性增殖生长、病情的进展关系密切。

Objective To explore the clinical significance of determination of changes of serum levels of polypeptide growth factors in patients with hepatocelhilar carcinoma or liver cirrhosis. Methods Serum levels of TGF -α,TGF- β1, AFP and AFU were determined with RIA in 32 patients with HCC, 34 patients with liver cirrhosis LC and 30 controls. Results; Serum levers of TGF -α, TGF -β1, AFP and AFU in patients with HCC were significantly higher than those in patients with LC and normals （ P 〈 0.05）. Serum levels of TGF -α, TGF -β1 in patients with LC were slightly higher than those in controls, but not sigmifieantly （ P 〉 0.05 ）, however, the AFP and AFU levels were significantly higer （P 〈 0.01）. Conclusion Over expression of TGF -α and TGF -β1 increased the proliferation activity of hepatic carcinoma cell and accelerated the malignant growth.