尖锐湿疣患者治疗前后血清TNF-α、hs-CRP和GM-CSF检测的临床意义

Clinical Significance of Determination of Changes of TNF-α,hs-CRP and GM-CSF Levels After Treatment in Patients with Condyloma Acuminatum

目的:探讨了尖锐湿疣患者治疗前后血清TNF-α、hs-CRP和GM-CSF水平的变化及意义。方法:应用放射免疫分析和免疫比浊法对62例尖锐湿疣患者进行了血清TNF-α、hs-CRP和GM-CSF检测,并与35名正常健康人作比较。结果:在治疗前尖锐湿疣患者TNF-α、hs-CRP和GM-CSF水平均非常显著地高于正常人组(P<0.01)。经3个月治疗后血清TNF-α、hs-CRP和GM-CSF水平与正常人组比较无显著性差异(P>0.05)。患者组治疗前后血清TNF-α、hs-CRP和GM-CSF水平也有显著性差异(P<0.01)。结论:检测尖锐湿疣患者血清TNF-α、hs-CRP和GM-CSF水平的变化对疾病的治疗、预后观察有重要的临床价值。

Objective To explore the significance of changes of serum TNF - α, ks - CRP and GM - CSF levels after treatment in patients with condyloma acuminatum. Methods Serum levels of GM -CSF （with RIA） and TNF -α, hs -CRP levels （with im- muno-turbidimetry method） were measured both before and after treatment in 62 patients with condyloma acuminatum and 35 controis. Results Before treatment, the serum TNF - α, hs - CRP and GM - CSF levels in the patients were significantly higher than those in controls （ P 〈 0.01 ）. After treatment for 3 months, the levels were not significantly different from those in controls （ P 〉 0. 05 ）. Serum TNF - α, hs - CRP and GM - CSF lends in patients before the treatment were significantly higher than those after treatment （ P 〈 0.01 ）. Conclusion The levels of serum TNF - v, hs - CRP and GM - CSF increased significantly in patients with condyloma acuminatum especially in those advanced cases.