新兵集训应激对肾上腺髓质激素的影响

Effect of Military Training Stress on Plasma Adrenomedullin (ADM) Levels in Recruits

目的:探讨新兵军事应激条件下肾上腺髓质激素及其代谢产物的变化规律。方法:采用放射免疫分析和微柱法对一个建制连新兵60人训练前后进行血浆肾上腺髓质激素(ADM)及尿液中香草扁桃酸(VMA)的检测,同时与50名老兵进行对照。结果:与老兵组比较,新兵组训练前及训练后血浆ADM及尿液中VMA的水平均显著升高(P<0.05;P<0.01;P<0.05;P<0.01),与训练前比较,高强度训练后ADM和VMA水平均明显增高(p<0.01;P<0.05),尤以ADM增高十分显著[训练前(23.72±12.63)pg/ml;训练后(214.97±57.75)pg/ml],其血浆中浓度较训练前增高9倍。结论:①新兵入伍及训练过程中可引起ADM和VMA的应激性增高。②适度的应激反应对人体有利,益于机体快速适应内外环境的变化;而急性强烈或反复的应激反应则是造成应激性损伤的危险因素。

Objective To investigate the effect of military training stress on the secretion and metabolism of adrenomedullin in reemits. Methods Plasma ADM （with RIA） and urinary VMA （with colorimetrie analysis） contents were determined both before and after lh strenuous military exercise in 60 newly enlisted soldiers and once in 50 soliders served over 3 years （ as controls）. Results For the recruits group, the plasma concentrations of ADM and urinary concentrations of VMA both before and after military training were significantly higher than those in veterans control （P 〈0.05, P 〈0.01, P 〈0.05, P 〈0.01 ）. High strength military training resuited in significant elevation of concentrations of both ADM and VMA （P 〈 0.01, P 〈 0.05）. The elevation of plasma ADM concentration was extremely significant with an amplitude about 9 times （23.72±12.63μg/ml before training and 214.97±57.75 μg/ml after training）. Conclusion①The stress of enroUment and military training may result in increase of secretion of ADM and VMA in recruits.②Appropriate stress is beneficial in terms of rapid adaptation for changes of internal and external environment, while excessive acute and repeated stress may be harmful.