甲亢和甲减患者治疗前后血清IGF-Ⅰ、hs-CRP检测的临床意义

Clinical Significance of Measurment of Changes of Serum IGF-Ⅰ,hs-CRP Levels After Treatment in Patients with Hyperthyroidism and Hypothyroidism

目的:探讨了甲亢和甲减患者治疗前后血清IGF-Ⅰ、hs-CRP水平的变化及意义。方法:应用放射免疫分析和免疫比浊法对36例甲亢和30例甲减患者进行了治疗前后血清IGF-Ⅰ、hs-CRP测定。并与35名正常健康人作比较。结果:在治疗前甲亢患者血清IGF-Ⅰ、hs-CRP水平均非常显著地高于正常人组(P<0.01),而甲减患者除hs-CRP水平高于正常人组外(P<0.01),血清IGF-Ⅰ水平则显著地低于正常人组(P<0.01),经3个月治疗后,除hs-CRP水平与正常人组比较无显著差异外(P>0.05),血清IGF-Ⅰ水平与正常人组比较仍有显著性差异(P<0.05)。结论:检测甲亢和甲减患者血清IGF-Ⅰ和hs-CRP水平的变化对了解病情、观察预后均具有重要的临床价值。

Objective To explore the clinical significance of changes of serum IGF-Ⅰ, ks - CRP levels after treatment in patients with hyperthyroidism and hypothyroidism. Methods Serum IGF -Ⅰ, ks - CRP （with RIA）, and serum ks -CRP （with immuno - turbidity methods levels were determined both before and after treatment in 36 cases of hyperthyroidism 30 cases of hypothyroidism as well as 35 controls. Results Before treatment, the serum IGF-Ⅰ levels in patients with hyperthyroidism were significantly higher and the levels in patients with hypothyroidism were significantly lower than those in controls （ both P 〈 0. 01 ）. After treatment for 3 months, the levels were much corrected, but still remained significantly different from those in controls （ P 〈 0. 05）. Before treatment serum ks - CRP levels in both groups of patients were significantly higher than those in controls （P 〈 0.01）, but after treatment, the levels were not much different from those in controls. Conclusion Serum levels of IGF -Ⅰ and hs - CRP were closely related to the disease process in patients with hyperthyroidism as well as in patients with hypothyroidism, and were much corrected after trentment.