结直肠癌患者血清VEGF和Endostatin水平与其临床病理特征的关系

Study on the Relationship Between the Serum Levels of VEGF,Endostatin and the Clinico-Pathological Features in Patients with Colo-Rectal Cancer

目的:探讨结直肠癌患者血清血管内皮生长因子(VEGF)、内皮抑素(Endostatin)水平与其临床病理特征的关系。方法:用ELISA检测了50例结直肠癌患者血清VEGF和Endostatin的水平,并与40例健康人作对照。结果:结直肠癌患者血清VEGF和Endostatin的水平均高于健康对照组(P<0.05),并与癌细胞的分化程度、肿瘤大小、浸润程度、有无淋巴结转移、有无远处转移、TNM分期密切相关(P<0.05)。结论:血清VEGF和En-dostatin的检测可作为结直肠癌诊断的一个有用的实验室指标,并可判断结直肠癌的恶性程度及进展情况。

Objective To study the relationship between the serum levels of VEGF endostatin and the clinico - pathological features in patients with colo - rectal cancer. Methods Serum levels of VEGF and endostafin were measured with ELISA in 50 patients with colo- rectal cancer and 40 controls. Results The serum levels of VEGF and Endostatin in patients with colo - rectal cancer were significantly higher than those in controls （ P 〈 0.05 ）. Among the patients, the serum levels in the patients with the clinico - pathological variables of poor differentiation, large size （over 5cm） deep infiltration positive regional lymph node metastasis or distant metastasis, and more advanced TNM stage were significantly higher those in patients without （ P 〈 0.05 ）. Conclusion The detection of blood serum VEGF and Endostatin is used as the indicator of cancer diagnosis for a swimming laboratory, and also can judge the malignant degree and progress of the colorectal cancer.