盐酸纳络酮对颅脑损伤患者血清C-反应蛋白影响的临床研究

Effect of naloxone on the concentration of plasma C-reaction protein following brain injuries

目的通过动态观察盐酸纳络酮对颅脑损伤患者血清C-反应蛋白浓度的影响,进一步探讨盐酸纳络酮在颅脑损伤治疗中的作用。方法将80例颅脑损伤患者随机分为纳络酮组和常规组。纳络酮组在常规治疗的基础上加用盐酸纳络酮,即入院后立即缓慢静脉推注4mg后以0.4mg/kg/天静脉泵持续静脉滴注,3天后改为0.2mg/kg/天,至第10天停药。两组患者于入院后24小时内和第10天检测血清C-反应蛋白浓度。治疗后3月采用GOS评分比较预后。结果两组患者血清C-反应蛋白浓度明显高于正常对照组(P<0.05);纳络酮组血清C-反应蛋白浓度明显低于常规组(P<0.05);纳络酮组治疗后3个月GOS评分明显高于常规组(P<0.05)。结论颅脑损伤患者血清C-反应蛋白浓度明显升高,盐酸纳络酮能显著降低患者血清C-反应蛋白浓度,保护神经功能,改善预后。

Objective Through observation the effect of naloxone on concentration of plasma C-reaction protein following brain injuries, to explore the treatment effect of edaravone on brain injury patients. Methods A total of 80 patients with brain injuries were divided into naloxone group and general group randomly. The patients of naloxone group were treated with naloxone besides general treatment. Concentration of C-reaction protein in serum was measured in all patients in 24h and 10d after hospitalization. Prognosis were evaluated after 3 month. Results The concentration of C-reaction protein in serum of both groups were significantly higher than of norulal group （P〈0.05） ; The concentration of C-reaction protein in serum of naloxone group were significantly lower than of general group（P〈0.05）. The GOS grade of naloxone group were significantly higher than of general group after 3 month （P〈0.05）. Conclusion The concentration of C-reaction protein in serum elevated significantly after brain injuries, naloxone could lower the concentration of C-reaction protein in serum ,protect neurofunetion and improve prognosis. ;