慢性心力衰竭患者B型钠尿肽与血小板参数的相关性观察

Correlation Between B-type Natriuretic Peptide and Platelet Parameters in Chronic Heart Failure

【目的】探讨慢性心力衰竭（CHF）患者B型钠尿）tk（BNP）与血小板参数的相关性。【方法】分别检测116倒CHF患者（CHF组）和60例非心衰心脏病患者（对照组）的BNP、血小板计数（PLT）、平均血小板体积（MPV）、血小板体积分布宽度（PDW）和大血小板比率（P-LCR），并进行对比性分析。【结果ICHF组的BNP水平明显高于对照组，差异有统计学意义（P〈0．01，z=7．276）；CHF组的MPV、PDW和P—LCR明显高于对照组，差异有统计学意义（均P〈0．01，t=4．203，8．484，5．760）；而两组间的PLT差异无显著性（P〉0．05，t=0．210）。CHF组患者BNP水平与MPV（r=0．246，P〈O．05）、PDW（r=0．299，P〈0．05）和P—LCR（r=0．329，P〈0．05）呈正相关。【结论】CHF患者血小板参数与BNP密切相关，检测这些指标有助于CHF患者的病情评估、疗效监测和预后判断。

[Objective] To investigate the relationship between B-type natriuretic peptide （BNP） and platelet parameters in chronic heart failure （CHF）. [Methods] The levels of plasma BNP and platelet parameters including platelet count （PLT）, mean platelet volume （MPV）, and platelet distribution width （PDW） as well as platelet large cell ratio （P-LCR） were measured between 116 cases of CHF （CHFgroup） and 60 patients with non-CHF heart disease （control group）, and the comparisons were performed hetween two groups. [Results] The level of BNP was considerably higher in the CHF group than that in the control group, showing a significant differences between two groups（ P〈0.01, =7. 276）. The values of MPV, PDW and P-LCR were markedly higher, with pronounced differences between two groups（all P〈0.01, t=4. 203,8. 484 ,and 5. 760, respectively）. And no significant difference was noted in PLT（ P〉0.05, t=0. 210）. The level of BNP was positively related to MPV （γ=0. 246, P〈0.05）, PDW （γ=0. 299, P〈0.05） and P-LCR （γ=0. 329, P〈0.05） in the CHF group. [Conclusion] Platelet parameters is closely associated with BNP in CHF. The detection of these indices can aid in assessing the disease severity, monitoring the efficacy and judging the prognosis of CHF.