热压大黄与生大黄对通便作用的比较研究

A Comparative Study of Laxative Effect

目的:探讨降低三黄泻心汤的不良反应。方法:采用热压法炮制大黄,制备三黄泻心汤,通过抑菌试验、泻下实验、小肠推进实验、对小鼠实热便秘模型的影响,对生大黄与热压大黄和生大黄泻心汤与热压大黄泻心汤进行比较。结果:各药在体外对所试菌种均有一定的抑制作用,大黄经热压炮制对泻下作用有影响,可使泻下缓减。结论:采用热压大黄制备三黄泻心汤,既能保持其抑菌作用,又能使其泻下作用缓和,可减轻不良反应。

Objective： To discuss to lower adverse reaction of San Huang Xie Xin Decoction. Methods： crude rhubarb processed by Hot-Pressing method was prepared in San Huang Xie Xin Tang, through antibacterial test, the experiment of laxation, small intestine propulsion laboratory, rhubarb compared influences on the mouse model of Heat constipation with Hot- Pressing rhubarb and rhubarb Xie Xin Tang with Hot- Pressing rhubarb Xie Xin Tang. Re- suits： by in vitro test for the bacteria, the drugs had inhibiting effect, rhubarb by hot- pressing had influence on diarrhea and can reduce laxation. Conclusion： the preparation of Hot- Pressing rhubarb Xie Xin Tang can not only maintain its bacteriostatic activity, but also can alleviate laxation effects, and can reduce adverse reaction.