抑癌基因启动子过甲基化对肺癌临床研究的意义

Value of anti-oncogene promoter hypermethylation on clinical research of lung cancer

抑癌基因启动子过甲基化是除基因突变和染色体物质缺失外抑癌基因失活的第3种机制，某些情况下是抑癌基因失活的惟一机制。目前抑癌基因启动子过甲基化已被用于肺癌的诊断、筛查和监测肿瘤复发的研究。本文对抑癌基因启动子过甲基化导致肺癌发生的基础、研究过甲基化的方法、过甲基化研究在临床的应用、逆转过甲基化的探讨及目前研究的局限性作一综述。

Except gene mutation and loss of heterozygosity,anti-oncogene promoter hypermethylation is another mechanism leading to anti-oncogene inactive,and it is the only mechanism in some condition. Now anti-oncogene promoter hypermethylation is used in the field of diagnosis, screening and monitoring relapse of lung cancer. This review summarizes mechanisms of anti-oncogene promoter hypermethylation leading to lung cancer, methods of hypermethylation, clinical application of hypermethylation, epigenetic therapies of hypermethylation and limit of current hypermethylation research.