吲哚胺-2，3-双加氧酶及其在肿瘤方面免疫调节的研究进展

Progression of indoleamine-2, 3-dioxygenase and immunoregulation in tumor

吲哚胺-2，3-双加氧酶是催化色氨酸沿犬尿氨酸分解代谢的限速酶，在哺乳动物组织和细胞中广泛表达。色氨酸耗竭及其代谢产物是调节免疫抑制和免疫耐受的重要机制，在多种生理和病理状态中发挥重要的作用。因此，吲哚胺-2，3-双加氧酶在器官移植、自身免疫性疾病和肿瘤等方商的治疗也成了研究的热点。

Indoleamine-2,3-dioxygenase（IDO） are the rate-limiting enzyme that initiates oxidative metabolism of tryptophan along the kynurenine pathway. IDO generally expresses in tissues and cells of mammals. Tryptophan depletion and tryptophan metabolism are important mechanisms in regulating the immune inhibition and the immune tolerance, and play a key role in many physiological and pathological condition. Thus, many studies focus on therapeutic effect of IDO on organ transplantation, autoimmune disease and tumor.