摘要
以非洛地平原料药为模板,分别采用丙烯酰胺,甲基丙烯酸及其两者按(1:1)的混合为功能单体,加入交联剂二甲基丙烯酸乙二醇酯,采用封管聚合法制备非洛地平的分子印迹聚合物,实验结果通过Scatchard方程分析可知,非洛地平(甲基丙烯酸)分子聚合物对非洛地平有着良好的选择性,可进一步应用于临床非洛地平药物的分离富集和检测.
Using three kinds of monomers as MAA,AM and MAA -AM（1.1） and a crosslinker （EGD- MA）, molecularly imprinted polymers（MIPs） with recognition properties to Felodipine were prepared on the condition of heating . The results evaluated by Scatchard analysis showed that MIP（Felodipine with MAA） had good selectivity against Felodipine. The next application is to separate, enrichment and determination of Felodipine clinically.
出处
《凯里学院学报》
2009年第3期37-39,共3页
Journal of Kaili University
基金
贵州省科学基金[黔基合计号:(2003)3009号]
关键词
非洛地平
功能单体
MIP
检测
Felodipine functional monomer Molecular imprinted polymer determination
