雅安市适龄儿童麻疹疫苗强化免疫前后抗体水平分析

Analysis of Measles Antibody Level of Ordinary Children Before and After Immunization

目的了解雅安市适龄儿童麻疹疫苗(MV)强化免疫前后麻疹抗体水平,为制定免疫规划,实现消除麻疹目标提供科学依据。方法采用ELISA(酶联免疫吸附试验)法对250人份MV强化免疫前后500份血清进行麻疹IgG抗体水平检测。结果MV强化免疫前阳性率为94.40%,麻疹IgG抗体平均浓度为1 524.24mlU/ml;MV强化免疫后阳性率为100%,麻疹IgG抗体平均浓度为1 893.14mlU/ml。强免前后抗体阳性率差异有统计学意义(χ2=14.40,P<0.05)),有MV免疫史的免前麻疹抗体阳性率显著高于未接种者(χ2=11.95,P<0.05))。结论雅安市适龄儿童麻疹抗体水平较高,强化免疫能提高人群免疫覆盖率,消除免疫空白。

Objective To investigate measles antibody level before and after immunization for the ordinary children, and to provide scientific basis for the goal to e-liminate measles. Method Measles antibody of 500 serum samples from 250 children before and after supplementary immunization of measles vaccine was detected with ELISA. Result The positive rate of IgG before supplementary immunization was 94. 40%, and the average concentration of IgG was 1 524. 24mlU/ml. The positive rate of IgG after supplementary immunization was 100%, and the average concentration of IgG was 1 893, 14mIU/ml. There were significant differences between before and after immunization in positive rate（ X^2 = 14. 40, P 〈 0. 05）. The IgG possitive rate before vaccination of children with measles raccination history was significantly higher than that of children had no measles, vaccination history （ X^2 = 11.95, P 〈 0. 05 ）. Conclusion The measles antibody level of ordinary children in Yaan was high, but measles prevention and control should still be intensified. Howerver, the routine immunization should be improved to keep immunization coverage and eliminate blank of immunization.