摘要
以聚碳酸酯聚氨酯(PCU)为基质材料,通过溶液浇铸法制备了PCU-COC(胆甾醇油烯基碳酸酯)和PCU-PPC(丙酰氧丙基纤维素)两种液晶复合膜。对复合膜的表面形貌和复合膜中液晶在PBS溶液中的流失率以及液晶种类和液晶含量对复合膜的溶血率、动态凝血性能和表面蛋白吸附的影响进行了详细研究。结果表明:两种液晶复合膜的溶血率均低于5%,符合生物材料溶血试验要求;两种复合膜的抗凝血性能均优于相应的基材PCU;与相应的PCU-PPC相比,PCU-COC复合膜的抗凝血性能较好,但PCU-COC复合膜中的COC在PBS溶液中较易流失。
Two kinds of polycarbonate urethane （PCU）-liquid crystal composite membranes were prepared based on cholesteryl oleyl carbonate（COC） and propoxypropyl cellulose（PPC） liquid crystal compounds by solution-cast method. The surface morphology and liquid crystal wastage rate in PBS solution of the composite membranes, and the effects of the kind and content of liquid crystal on the hemolysis ratio, dynamic blood clotting property and surface protein adsorption of composite membranes were studied. The results showed that the hemolysis ratio of two kinds of PCU-liquid crystal composite membranes were lower than 5%, conforming to the HR value of biomaterials. The property of dynamic blood clotting of two kinds of composite membranes are better than that of pure PCU. Compared to that of PCU-PPC, the property of dynamic blood clotting of PCU-COC was better, but the COC in composite membrane was prone to flow out in PBS solution.
出处
《功能高分子学报》
CAS
CSCD
北大核心
2009年第2期119-123,共5页
Journal of Functional Polymers
基金
国家自然科学基金(30500128)
国家高技术研究发展计划(863计划)
关键词
聚碳酸酯聚氨酯
液晶
复合膜
血液相容性
polycarbonate urethane
liquid crystal
composite membrane
blood compatibility
