支气管肺癌患者血小板活化状态检测的临床意义

The detection and clinic significance of platelet activation of bronchial lung cancer

目的观察肺癌患者血小板黏附因子的表达和血小板活化状态，探讨血小板功能异常与病情的关系。方法采用流式细胞术对60名健康人和164例肺癌患者血小板活化标志物CD31、TSP、CD36、CD62、CD63水平进行检测，对比其在健康人与不同病期、不同病理类型的肺癌患者之间的异同。结果与对照组比较，早中期组（A组）CD31、CD36、CD62、CD63表达增强（P〈0．05～0．01）；手术后组（B组）CD36、CD36、CD62、CD63差异均无统计学意义（P〉0．05）；晚期组（C组）CD31、CD36、CD62、CD63表达增强（P均〈0．01）；与A组比较，B组CD36、CD62、CD63表达减少（P〈0．05—0．01）；C组CD31、TSP、CD36、CD62、CD63表达增强（P〈0．05—0．01）；与小细胞癌比较，腺癌TSP、CD36、CD62、CD63，鳞癌CD36、CD62、CD63，肺泡癌CD36、CD62、CD63表达均减少（P均〈0．05）。结论血小板活化过度普遍见于不同病期肺癌患者，手术后活化程度减轻，晚期肺癌较重。小细胞肺癌血小板活化可能较显著。

Objective To investigate the adhesion molecule expression and functional status of platelets in lung cancer patients, and their relations with disease progression. Methods Using flow cytometry to measure the expression of surface antigens and functional status of platelets in 60 healthy control group, and 164 lung cancer patients. Results Comparing with control group, the expression in early group and mid term group（A group） of CD31, CD36, CD62, CD63 increased, and there is no significant meaning in the differences of surgery group （B group） of CD31, TSP, CD36, CD62, CD63. The expression in advanced group （C group） of CD31, TSP, CD36, CD62, CD63 increased. Comparing with A Group, the expression in B Group of CD36, CD62, CD63 decreased. The expression in C group of CI）3l, TSP, CD36, CD62, CD63 increased. Comparing with the small cell lung cancer, the expression of adenocarcinoma of TSP, CD36, CD62, CD63, squamous cell carcinoma of CD31, CD62, CD63, and alveolus cancer of CD31, TSP, CD63, all decreased. Conclusion The high level expression of platelet activation exists in patients with lung cancer of different stage, and decreased after operation： Platelet activation expressed significantly in the advanced stage of small cell lung cancer.