抗肿瘤Lamellarin类生物碱的合成研究新进展

Recent Advances in the Synthesis of Lamellarins as Anticancer Alkaloids

Lamellarin类化合物是从海洋软体动物中分离得到的一类生物碱.Lamellarin类生物碱及其类似物具有良好的抑制肿瘤细胞增殖、逆转p-糖蛋白介导的多药耐药等活性,显示出成为抗肿瘤候选药物的潜力.近年来,对Lamellarin类生物碱结构改造和新型杂合体及类似物的研究,已成为新型抗肿瘤候选药物研究的热点之一.综述了Lamellarin类生物碱的全合成策略与技术等方面的研究新进展.

The lamellarins, a group of natural pyrrole alkaloids with interesting anticancer activities, were firstly isolated from a prosobranch mollus Lamellaria sp.. Due to their multidrug resistance （MDR） reversal in some cancer cell lines, total synthesis and structure modifications of lamellarins to provide drug candidates for the treatment of cancer have become one of the most promising project in the area of novel anticancer drug discovery. In this article, the latest results and progresses regarding the synthesis and modification of lamellarins are reviewed.