高血压患者胰岛素抵抗及其与血脂的关系

Relationship Between Insulin Resistance and Serum Lipid in Patients With Hypertension

目的:初步探讨高血压非糖尿病患者胰岛素敏感性及其与血脂水平的关系。方法:收集高血压患者82例,对照组76例,测定空腹胰岛素(FINS)浓度及空腹血糖(FPG),计算胰岛素敏感性指数(ISI);测定胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C);测量身高、体重,计算体重指数(BMI)。结果:①高血压组较对照组FINS增高(21.39±14.21vs14.48±11.32,P<0.05),ISI降低(-4.59±0.52vs-4.18±0.54,P<0.05),TG升高(2.96±0.58vs1.30±0.50,P<0.05),HDL-C降低(1.30±0.07vs1.86±0.12,P<0.05)。②以ISI为因变量的多元逐步回归分析显示,影响因素为TG、SBP、BMI和HDL-C(r2=0.64,P<0.05)。结论:高血压患者更多存在胰岛素抵抗(IR)和血脂异常,IR与TG、SBP、BMI和HDL-C等因素密切相关。

Objective： To investigate the relationship between insulin resistance （IR） and serum lipid in patients with hypertension. Methods： Eighty-two patients with hypertension and 76 controls were included. Concentrations of fasting insulin （FINS） and fasting plasma glucose （FPG） were detected, and insulin sensitivity index （ISI） was calculated. Blood lipids （TC, LDL-C, HDL-C and TG）, body height and weight were detected, and body mass index （BMI） was calculated. Results：① FINS（21.39± 14. 21 vs 14. 48±11.32,P〈0. 05） and TG （2. 96± 0. 58 vs 1.30± 0. 50,P〈0. 05） elevated; ISI （ -4. 59±0. 52 vs - 4. 18±0. 54,P〈0. 05） and HDL-C （1.30±0. 07 vs 1.86 ± 0. 12, P〈0. 05） decreased in patients with hypertension.② In a multiple linear step-wise regression analysis, with ISI as dependent variable and other factors as independent variables, TG, SBP, BMI and HDL-C were the main determinants for ISI（r^2 = 0. 64,P〈0. 05）. Conclusions： Insulin resistance and dyslipidemia usually present in patients with hypertension. TG, SBP, BMI and HDL-C closely relate to IR in patients with hypertension.