聚乙烯醇模板中原位水热法羟基磷灰石纳米颗粒的控制制备及表征

In situ hybridization hydroxythermal synthesis and characterization of nanometer hydroxyapatite in poly(vinyl alcohol) matrix

具有生物活性和生物相容性的羟基磷灰石/高分子复合材料的合成和可控制备,是当今生物材料领域研究的重要热点,在生物可降解聚乙烯醇高分子模板中,采用原位水热法,系统研究了具有生物活性的纳米HAP的可控制备,并对水热时间和模板剂浓度对羟基磷灰石/聚乙烯醇复合材料中HAP微粒形貌、大小的影响进行系统研究。结果表明,水热时间从0h增加到16h,PVA/HAP微粒中HAP形貌逐渐由不规整的球状、短棒状变为规整的长棒状,水热时间从16h增加到72h,长棒状的PVA/HAP微粒的形貌变化不大;模板高分子(聚乙烯醇)浓度越大,获得的HAP微粒越小。

Syntheses and controllable preparation of nanometer hydroxyapatite/polymer composites with bloactlvity and biocompatibility have been an important research direction in the field of medical and biological materials and attracted great interest. This paper systematically studied controllable preparation of nanometer hydroxyapatite（HAP） via in-situ hydroxythermal synthesis method using poly（vinyl alcohol）（PVA） as molecular template. Furthermore, the effect of hydroxythermal reaction time and template agent concentration on size and mor- phology of HAP particles in the composites was systematically studied. The results show that the morphology of HAP/PVA composites grow from irregular spherical and short rod-like particle to regular long rod-like particle with increase of hydroxythermal reaction time from 0 to 16h. However,the morphology don＇t obviously change when the hydroxythermal reaction time increase from 16 to 72h. Simultaneously,it was found that the crystallite size of HAP in HAP/PVA composites become small with the increase of template agent PVA concentration.