中年人血清尿酸水平与冠心病的关系

Relationship of serum uric acid level to risk of coronary heart disease in young adults less than 50 years old in age

目的探索年龄小于50岁患者的血尿酸与冠心病的关系。方法收集近3年间经冠脉造影证实为冠心病患者与非冠心病患者的临床资料,包括性别、年龄、血尿酸、血糖、血脂、体重指数、冠脉造影结果等,分析两组之间血尿酸水平;多元回归方法分析血尿酸与冠心病的关系。结果冠心病组血尿酸水平明显高于非冠心病组(P=0.003)。冠心病双支和多支病变的患者血尿酸水平均高于明显单支病变(P<0.05;P<0.01)。多元组步回归分析证实在调整了其他危险因素外,血尿酸与冠心病病变严重程度密切相关(P=0.005)。结论血尿酸升高是50岁以下冠心病患者的独立危险因素。

Objective To investigate the relationship of serum uric acid level （SUAL）to the risk of coranary artery disease. Methods 156 young adults （ 〈 50 years ） hospitalized during January 2005 to April 2008 were diveded into coronary artery disease （CAD） group （ 96 cases） and control group （ 60 cases ） according to coronary angiography. The CAD group was then sub-divided into the there groups：single-vessel group（ n = 55 ）, double-vessel group（ n =21 ）and multi-vessel group（ n =20）. The relationship of serum uric aeid（SUAL）to the risk of CHD was analyzed. Results The SUAL in CAD group was higher than that in control group （P = 0. 003 ）. Moreover, the SUAL was associated with the severiety of CAD. Multiple regression analysis revealed that SUAL was independently associated with the severity of CAD after adjusting for other risk factors. Condusion Increased level of SUAL was an independent risk factor of CAD in adults younger than 50 years old.