晚期胰腺癌区域性动脉灌注化疗25例临床分析

Clinical analysis of twenty-five cases with advanced pancreatic carcinoma treated by arterial infusion regional chemoherapy

目的探讨晚期胰腺癌区域性动脉灌注化疗的有效性。方法采用单管或多管动脉插管为25例晚期不能切除胰腺癌患者进行区域性灌注化疗。结果25例患者均有不同程度腹痛、腹胀减轻,黄疸消退,体质量上升。术前需要镇痛治疗10例,其中9例停用镇痛药,1例减量,随访23例,平均生存期16个月。结论区域性动脉灌注化疗为晚期不可切除胰腺癌患者提供一个新的比较有效的治疗方法,他可以减轻患者的症状,延缓肿瘤生长速度,延长患者生存期。

Objective To explore the efficacy of arterial infusion chemotherapy （AIRC）on advanced pancreatic carcinoma. Methods Twenty-five patients with advanced pancreatic carcinoma which could not be excised were given arterial infusion regional chemotherapy by one or more catheters. Results All thepatients＇ symptoms such as abdominal pain, distension were alleviated in different level, jaundice disappeared, the patients＇ weight increased. Ten patients depended on analgesics reduced in the other one. Following-up twentythree months, the average survival time was sixteen months. Conclusion Arterial infusion regional chemotherapy provides a new and effective therapy method for advanced pancreatic carcinoma. It can alleviate the clinical symptoms, postpone the growth speed of tumor and prolong the survival time of the patients