噻唑烷二酮类药物的抗肿瘤作用

Antineoplastics effects of thiazolidinediones

噻唑烷二酮(TZDs)是用于治疗以胰岛素抵抗为特征的2型糖尿病的药物。它主要通过作用于核受体家族中的过氧化物酶增殖体的激活受体γ(PPARγ)来发挥抗糖尿病的作用。近年来,越来越多的实验证据发现其具有一定的抗肿瘤作用,涉及的机制主要有诱导细胞周期的终止,促进细胞的凋亡或分化,抑制肿瘤的转移及血管新生等。

The thiazolidinediones （TZDs） are a class of synthetic compounds for the treatment of type 2 diabetes mellitus. TZDs are known as activators of peroxisome proliferators-activated receptor-γ（ PPAR-γ）, and exert their antidiabetic action largely through the nuclear receptor family. Interestingly, increasing evidences have shown that TZDs exert antineoplastic effects via the mechanisms such as induction of cell cycle arrest,proapoptotic effects, induction of cellular differentiation, inhibition of angiogenesis and potential metastasis.