实验性脾虚证大鼠甲状腺及甲状旁腺形态学与细胞化学研究

Morphological and Cytochemical Study on Thyroid and Parathyroid Glands of Rats with Experimental Spleen Deficiency Syndrome

对实验性脾虚证大鼠的甲状腺与甲状旁腺进行了形态学与细胞化学观察。形态学显示：脾虚证大鼠甲状腺滤泡变得不规则，滤泡上皮呈低立方状，滤泡间隙变宽；甲状旁腺变化不明显。细胞化学显示甲状腺滤泡细胞酸性磷酸酶（ＡＣＰ）和滤泡液的ＰＡＳ反应明显减弱（Ｐ＜０．０１，Ｐ＜０．０５）。甲状旁腺碱性磷酸酶（ＡＬＰ）增强（Ｐ＜０．０５），而ＡＣＰ减弱（Ｐ＜０．０１）。

hyroid and parathyroid glands of rats with experimental spleen deficiency syndrome were studied by morphological and cytochemical methods. The results of morphological observation showed that thyroid follicles appeared irregular, follicular epithela became low cuboidal and folliclar space became wider than normal. No obvious changes were observed in parathyroid glands. Cytochemical study results showed that the activity of ACP in thyroid follicular cells and PAS of colloid were weaker than normal. LDH and ALP activity in parathyroid glands cells were stonger, whereas ACP activity became weaker. This research demonstrated that thyroid and parathyroid glands of rat with experimental spleen deficiency syndrome underwent pathological changes.