摘要
实验用Balb／c小鼠经亚致死剂量的射线照射后，输入取自DBA／2小鼠的胸腺淋巴结细胞来制作免疫介导性再障的模型。用正气活血、温补脾肾、扶正解毒中药煎出液，分别浓缩成含生药量为0．79g／ml浓度的药液灌胃，每日1次，每次0．5ml。探讨这些方药对免疫介导型再障的治疗效果和作用机理。结果表明：这些方药在不同程度上都能提高再障小鼠的TH细胞，降低TS细胞，使TH／TS比值升高，减轻免疫异常对骨髓造血细胞的抑制和损伤，有利于再障骨髓造血的修复和重建。提示了辨证论治对指导用药的重要性。
The model of immune-mediated aplastic anenda in Balb/c mice was established by means of sublethal dose of radioactive ray irradiation and infusion of lymphocyte of thymus gland of DBA/2 mice. The mice were fed with three concentrated herbal decoctions respectively for supplementing qi and activating blood circulation, warming and invigorating the spleen and kidney, strengthening the body resistance and removing toxic substances,once daily with a dosage of 0. 5ml. The effects of these prescriptions and their therapeutic mechanism were observed. The results showed that these prescriptions could increase TH lymphocyte, reduce TS lymphocyte, raise TH/TS ratio and lessen the inhibition and injury of hematopoietic cell of bone marrow due to dysimmunity. These actions help the repaire and rebuild of hematopoietic cell of bone marrow.
出处
《中国中医急症》
1998年第3期128-130,共3页
Journal of Emergency in Traditional Chinese Medicine
