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原发性卵巢功能不全的候选基因研究进展 被引量：3

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摘要 卵巢早衰（premature ovarian failure，POF）是指女性40岁之前因性腺功能衰竭出现绝经，伴有促性腺激素水平升高、雌激素水平降低等内分泌异常及生殖器官萎缩等围绝经期表现。最近国际学者认为，POF的概念存在局限性，其仅代表卵巢功能的终末阶段，无法体现疾病的发展性和多样性，提出原发性卵巢功能不全（primary ovarian insufficiency，POI）是对这一疾病更加科学准确的诠释，揭示了疾病的本质特征。较大样本的临床病例分析认为，对于外源性因素导致的卵巢功能继发性丧失者，POF是对POI的补充。
作者 秦莹莹 陈子江
机构地区 山东大学附属省立医院生殖医学中心
出处 《中华妇产科杂志》 CAS CSCD 北大核心 2009年第6期472-474,共3页 Chinese Journal of Obstetrics and Gynecology
关键词 原发性卵巢功能不全 基因研究进展 雌激素水平 候选 临床病例分析 围绝经期 内分泌异常 外源性因素
分类号 R686 [医药卫生—骨科学]
  • 相关文献

参考文献28

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二级参考文献13

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共引文献15

同被引文献82

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引证文献3

二级引证文献25

中华妇产科杂志
2009年 第6期

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