贝伐单抗在卵巢上皮性癌化疗中的应用进展
被引量:1
摘要
卵巢上皮性癌(卵巢癌)是常见的妇科恶性肿瘤,居女性恶性肿瘤死亡原因的第4位。近30年来,随着化疗方案的改进,卵巢癌的5年生存率从过去的37%提高到目前的45%,但仍有75%的卵巢癌患者诊断时已属晚期(Ⅲ~Ⅳ期),经肿瘤细胞减灭术+标准一线化疗[即紫杉醇+卡铂(TC)方案]后,多数患者可获临床完全缓解,但仍有50%以上的患者复发,终因肿瘤耐药而死亡。为改善卵巢癌患者的预后,世界范围内各大肿瘤中心正致力于研究卵巢癌的不同治疗策略(如巩固治疗、腹腔化疗等)和开发新的细胞毒化疗药物及针对特异性分子靶点的生物制剂,
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
2009年第6期475-477,共3页
Chinese Journal of Obstetrics and Gynecology
参考文献20
-
1Ozols RF. Systemic therapy for ovarian cancer: current status and new treatments. Semin Onco1,2006,33 : S3-11.
-
2Rosa DD, Clamp AR, Collinson F, et al. Antiangiogenic therapy for ovarian cancer. Curr Opin Oncol,2007,19:497-505.
-
3Mesiano S, Ferrara N, Jaffe RB. Role of vascular endothelial growth factor in ovarian cancer: inhibition of ascites formation by immunoneutralization. Am J Pathol, 1998,153 : 1249-1256.
-
4Aghajanian C. The role of bevacizumab in ovarian cancer: an evolving story. Gyneeol Oncol,2006,102 : 131-133.
-
5Garzetti GG, Ciavattini A, Lucarini G, et al. Vascular endothelial growth factor expression as a prognostic index in serous ovarian cystoadenocarcinomas: relationship with MIB1 immuuostaining. Gynecol Oncol, 1999,73:396-401.
-
6Tuma RS. Success of bevacizumab trials raises questions for future studies. J Natl Cancer Inst,2005 ,97 :950-951.
-
7Monk B J, Choi DC, Pugmire G,et al. Activity of bevacizumab (rhuMAB VEGF ) in advanced refractory epithelial ovarian cancer. Gynecol Oncol,2005,96:902-905.
-
8Kaye SB. Bevacizumab for the treatment of epithelial ovarian cancer: will this be its finest hour? J Clin Oncol,2007,25:5150- 5152.
-
9Burger RA, Sill MW, Monk BJ, et al. Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: a Gynecologic Oncology Group Study. J Clin Oncol,2007,25:5165-5171.
-
10Cannistra SA, Matulonis UA, Penson RT, et al. Phase Ⅱ study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous cancer. J Clin Oncol,2007,25:5180-5186.
二级参考文献9
-
1Freidlin B, Korn EL, Hunsberger S, et al. Proposal for the use of progression-free survival in unblinded randomized trials. J Clin Oncol, 2007, 25:2122-2126.
-
2Hudis CA, Barlow WE, Costantino JP. Proposal for standardized definitions for efficacy end points in adjuvant breast cancer trials: The STEEP system. J Clin Oncol, 2007, 25:2127-2132.
-
3Jaffe CC. Measures of response: RECIST,WHO, and new alternatives. J Clin Oncol, 2006, 24:3245-3251.
-
4Benjamin RS, Choi H, Macapinlac HA, et al. We should desist using RECIST, at least in GIST. J Clin Oncol, 2007,25: 1760- 1764.
-
5Kelloff GJ, Sigman CC. New science-based endpoints to accelerate ontology drug development. Eur J Cancer, 2005,41:491-501.
-
6Choi H, Charnsangavej C, Faria SC, et al. Correlation of computed tomography and positron emission tomography in patients with metastatic gastrointestinal stromal tumor treated at a single institution with imatinib mesylate: proposal of new computed tomography response criteria. J Clin Oncol, 2007, 25:1753-1759.
-
7Therasse P, Arbuck SG, Eisenhauer EA, et al. New guidelines to evaluate the response to treatment in solid tumors. J Natl Cancer Inst, 2000, 92:205-216.
-
8Flaherty KT. Sorafenib in renal cell carcinoma. Clin Cancer Res 2007, 132(Suppl) :747s-752s.
-
9Flaherty KT, Rosen MA, Heitjan DF, et al. Pilot study of DCE- MRI to predict progression-free survival with sorafenib therapy in renal cell carcinoma. Cancer Biol Ther, 2008, 7 : 1-6.
共引文献6
-
1周杨,侯英勇,谭云山,卢韶华,侯君,刘景磊,秦净,沈坤堂,孙益红.甲磺酸伊玛替尼靶向治疗胃肠道间质瘤的耐药机制研究[J].中华肿瘤杂志,2009,31(8):597-601. 被引量:3
-
2尤长宣,苏瑾,李金瀚,盛信秀,崔斐,罗荣城.28例吉非替尼—线治疗老年非小细胞肺癌的临床经验[J].中国肿瘤临床,2010,37(11):640-642. 被引量:2
-
3徐立涛,陈震,林钧华,周振华,陈颢,孟志强,刘鲁明.经导管肝动脉化疗栓塞联合索拉非尼治疗中晚期肝细胞癌的临床观察[J].中华肿瘤杂志,2010,32(9):703-705. 被引量:6
-
4李杰,林洪生,侯炜,花宝金.中医药治疗肿瘤理念及策略[J].中国肿瘤,2010,19(11):735-738. 被引量:50
-
5鲁光平,潘骥群,邵柏,于志坚.肝细胞癌分子靶向治疗现况与展望[J].现代肿瘤医学,2013,21(1):208-212. 被引量:6
-
6魏涛.含奥沙利铂化疗方案用于治疗原发性肝癌的临床疗效及对患者免疫功能及肿瘤标志物的影响[J].实用癌症杂志,2021,36(9):1463-1466. 被引量:12
同被引文献12
-
1Siegel R, Ward E, Brawley O, et al. Cancer statistics, 2011 :the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin,201 1,61:212-236.
-
2Pliarchopoulou K, Pectasides D. Epithelial ovarian cancer: focus on targeted therapy. Crit Rev Oncol Hematol,2011,79:17-23.
-
3Ozols RF, Bundy BN, Greer BE, et al. Phase BI trial of carboplatin and paclitaxel compared with cisplatin and paclitaxel in patients with optimally resected stage Ili ovarian cancer: a Gynecologic Oncology Group study. J Clin 0ncol,2003,21:3194- 3200.
-
4Medina PJ, Goodin S. Lapatinib: a dual inhibitor of human epidermal growth factor receptor tyrosine kinases. Clin Tber,2008,30:1426-1447.
-
5Tsang RY, Finn RS. Beyond trastuzumab: novel therapeutic strategies in HER2-positive metastatic breast cancer. Br J Cancer, 2012, 106:6-13.
-
6Gareia AA, Sill MW, Lankes HA, et al. A phase Ⅱ evaluation of lapatinib in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: a gynecologic oncology group study. Gynecol 0ncol,2012,124:569-574.
-
7Dai CL, Tiwari AK, Wu CP, et al. Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2. Cancer Res, 2008,68:7905-7914.
-
8Paes MF, Dalto6 RD, Madeira KP, et al. A retrospective analysis of clinicopathological and prognostic characteristics of ovarian tumors in the State of Esptrito Santo, Brazil. J Ovarian Res,2011, 4:14.
-
9Ciardiello F. Epidermal growth factor receptor inhibitors in cancer treatment. Future Onco1,2005 ,1:221-234.
-
10Lee CS, Kim YJ, Jang ER, et al. Akt inhibitor enhances apoptotic effect of carboplatin on human epithelial ovarian carcinoma cell lines. Eur J Pharmacol,2010,632:7-13.
-
1管增伟,王盛兰,李勇.半胱氨酸蛋白酶与细胞凋亡[J].国外医学(肿瘤学分册),2000,27(5):280-282. 被引量:16
-
2张康,左强,罗荣城.吉非替尼治疗36例晚期非小细胞肺癌[J].中国癌症杂志,2006,16(10):878-879. 被引量:15
-
3Jeffrey,A.Meyerhardt,M.P.H,Robert,J.Mayer,杨昌山.结直肠癌的系统治疗[J].中国处方药,2005(10):23-25. 被引量:3
-
4温宏武,刘书文,郝纯毅,何洛文.卵巢癌P-糖蛋白表达及其与化疗耐药关系的研究[J].北京医学,1996,18(5):310-311.
-
5缪懿,祁澜,万小平.卵巢透明细胞癌化疗耐药的分子生物学研究进展[J].国外医学(妇产科学分册),2007,34(1):69-72. 被引量:3
-
6李君.胸腔内注射卡铂联合放疗治疗癌性胸水30例[J].现代医药卫生,2007,23(24):3738-3738.
-
7郑华金,袁良平.自体骨髓移植在恶性血液病和实体瘤中的应用[J].西南国防医药,1994,4(6):371-373.
-
8张秀兰,曲飞,赵东,刘惠萍.肺平滑肌瘤病1例报道及文献复习[J].诊断病理学杂志,2001,8(5):288-289. 被引量:3
-
9于红,关玉霞.1例以皮肤结节首发的非霍奇金淋巴瘤病人的护理[J].中华现代护理杂志,2010,16(20):2459-2460.
-
10张绍林.异基因骨髓移植治疗多发性骨髓瘤[J].国外医学(输血及血液学分册),1994,17(5):300-301. 被引量:1