耳鸣患者听觉皮质BOLD-fMRI研究

Blood oxygenation level dependen fMRI of auditory cortex in patients with tinnitus

目的利用血氧水平依赖(blood oxygenation level dependent,BOLD)功能磁共振成像(functional magnetic resonance imaging)(BOLD-fMRI)技术观察耳鸣患者纯音刺激时大脑皮质区激活情况,探讨耳鸣的客观检查方法。方法对7例长期耳鸣患者行BOLD-fMRI检查,观察其大脑皮质区激活信号,15例健康人作为对照组。结果15例健康志愿者纯音刺激时颞叶区均出现激活,颞上回激活率最高。刺激单耳时对侧听觉皮质激活体积和信号强度明显大于同侧(P<0.01),表现为对侧半球传导优势。耳鸣组纯音刺激时大脑皮质激活解剖部位、激活体积和信号强度无明显规律。结论长期耳鸣患者可能存在听觉皮质的异常神经活动。

Objective To investigate possible utility of blood oxygenation level-dependent functional magnetic resonance imaging （BOLD-fMRI） of the brain cortex in response to pure tone stimulation as objective measures for tinnitus. Methods BOLD-fMR] was performed in 7 patients with chronic tinnitus and 15 control subjects to record activation in the auditory cortex in response to pure tone stimulation. Results Activation was found in the temporal lobe in control subjects, with different volumes and intensities between the contralateral and ipsilateral cortices （P〈0.01）. In contrast, there lacked clear regularity in the anatomical locations, volume and intensity of activation in tinnitus patients. Conclusions BOLD-fMRI may be useful revealing abnormal neural activity in the auditory cortex in patients with chronic tinnitus.