帕金森病患者认知功能与尿酸及相关因素分析

Study on uric acid and the related factors associated with cognition in the patients with Parkinson＇s disease

目的探讨帕金森患者认知功能和血尿酸水平的关系并对认知功能相关因素进行分析。方法对104例PD患者进行认知功能评分和抑郁评分，收集其空腹血尿酸标本，对有无认知功能障碍的两组血尿酸进行比较，并用多重线性回归对认知功能相关因素进行分析。结果（1）有认知功能障碍组的血尿酸（249μmol／L±59μmol／L）低于无认知功能障碍组（323μmol／L±52μmol／L），差异有统计学意义（t=-6．78，P〈0．001）。（2）PD患者的认知功能水平与教育水平、血尿酸水平、年龄、H—Y分期和抑郁程度有相关性，与性别、吸烟、身高体重指数（BMI）和病程无相关性。结论（1）PD患者认知功能障碍与血尿酸水平降低有关，血尿酸水平越低，认知功能水平越低。（2）PD患者的教育水平、年龄、H-Y分期和抑郁严重程度影响认知功能的改变。

Objective To explore the relation of cognition and uric acid in Parkinson＇s disease and analyze the related factors of cognition. Methods A total of 104 patients with Parkinson＇s disease were divided into two groups：those with cognitive impairment and those without. Every patient was subject to the cognitive and depression function assessment. And the fasting blood uric acicl samples. Then the serum uric acid levels of two groups and analyze the related factors of the cognitive with multiple linear. Results （ 1 ） The serum uric acid level in the group with cognitive impairment（249 μmol/L ±59 μmol/L） is lower than that without cognitive impairment（323 μmoL/L ± 52 μmol/L） ,and there was marked statistical significance （t = -6. 78, P 〈 0. 001 ） （2）In PD patients, the cognitive scores correlated with serum uric acid levels, education,age,H-Y stages and the depression levels ,but didn＇t with gender,disease duration, smoking and BMI. Conclusion （ 1 ） There was correlation between the serum uric acid and the cognitive impairment. Low serum uric acid level predicted worse cognitive scores. （2） In PD, the change of the cognitive function was impacted by their education, age, H-Y stages and depression levels.