米非司酮对人绒毛和蜕膜内纤维粘连蛋白表达的影响

Effects of mifepristone on fibronectin in human villus and deciduas

目的观察米非司酮终止早孕后,绒毛和蜕膜内纤维粘连蛋白(FN)的表达情况。方法宫内早孕要求终止妊娠且孕龄<49 d的妇女,分为药物完全流产组(n=15)、药物不全流产组(n=15)和对照组(手术流产组,n=15)。两药物流产组取服药(米非司酮配伍米索前列醇)第3天排出的绒毛和蜕膜组织,对照组取负压吸引出的绒毛和蜕膜组织。采用免疫组化法测定绒毛和蜕膜组织中FN的表达。结果对照组绒毛和蜕膜FN的阳性表达率明显高于两药物流产组(P<0.017);其中,不完全流产组绒毛和蜕膜组织中FN的阳性表达率高于完全流产组(P<0.017)。结论米非司酮可通过降低早孕妇女绒毛和蜕膜中FN的表达,改变胚胎宫内发育的内环境,在细胞外基质水平发挥抗早孕的作用。

Objective To investigate the effects of mifepristone on the expression of fibronectin （FN） in human villus and deciduas after termination of pregnancy. Methods Women with choice of termination of pregnancy（ 〈49 d） were divided into medical abortion complete group （n = 15）, medical abortion incomplete group（n = 15） and control group （with dilatation and curettage, n = 15）. The villus and deciduas were collected at the third day of medical abortion or at the day of dilatation and curettage, lmmunohistochemical technique was used to examine the expression of FN in villus and deciduas of these three groups. Results The positive expression rates of FN in villus and deciduas of control group were significantly higher than those of two medical abortion groups（ P 〈 0. 017）, and the positive expression rates of FN of medical abortion incomplete group were significantly higher than those of medical abortion complete group （P 〈 0. 017）. Conclusion Mifepristone can decrease the expression of FN in human villus and deciduas and interfere the condition of embryonic growth, exerting the anti-gestational effect at extracellular matrix level.